Saul J Karpen Selected Research

Glucose (Dextrose)

1/2016	Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.
9/2013	Do therapeutic bile acids hit the sweet spot of glucose metabolism in NAFLD?

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Saul J Karpen Research Topics

Disease

29	Liver Diseases (Liver Disease) 11/2023 - 11/2005
27	Biliary Atresia 03/2024 - 10/2002
24	Cholestasis 03/2024 - 03/2002
15	Inflammation (Inflammations) 01/2023 - 08/2002
12	Fibrosis (Cirrhosis) 01/2023 - 04/2010
9	Non-alcoholic Fatty Liver Disease 01/2023 - 09/2013
8	Alagille Syndrome (Alagille-Watson Syndrome) 12/2023 - 12/2014
7	Pruritus (Itching) 12/2023 - 10/2018
6	Cardiomyopathies (Cardiomyopathy) 01/2023 - 10/2011
5	End Stage Liver Disease 11/2020 - 03/2006
4	progressive familial intrahepatic 1 Cholestasis 08/2023 - 05/2011
4	Disease Progression 01/2022 - 01/2015
3	Portal Hypertension 12/2023 - 01/2018
3	Acute Liver Failure (Fulminant Hepatic Failure) 01/2023 - 01/2006
3	Neoplasms (Cancer) 05/2010 - 08/2004
2	Ascites 12/2023 - 12/2020
2	Necrosis 01/2023 - 11/2008
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2023 - 01/2017
2	Ciliopathies 01/2023 - 01/2018
2	Fever (Fevers) 01/2022 - 10/2002
2	Malnutrition (Nutritional Deficiencies) 01/2022 - 07/2006
2	Body Weight (Weight, Body) 01/2020 - 03/2015
2	Intrahepatic Cholestasis 01/2019 - 12/2014
2	Avitaminosis (Vitamin Deficiency) 01/2018 - 12/2014
2	Liver Failure 10/2009 - 11/2006
2	Respiratory Insufficiency (Respiratory Failure) 11/2006 - 10/2006
2	Acute-Phase Reaction 06/2006 - 08/2004
1	Hemorrhage 12/2023
1	Rare Diseases (Rare Disease) 12/2023
1	Hyperbilirubinemia 11/2023
1	Diseases Newborn Infant 10/2023
1	Cholangitis 12/2020
1	Metabolic Diseases (Metabolic Disease) 10/2020
1	Obesity 10/2020

Drug/Important Bio-Agent (IBA)

29	Bile Acids and Salts (Bile Acids)IBA 01/2024 - 08/2002
12	BilirubinIBA 01/2023 - 03/2002
8	Biomarkers (Surrogate Marker)IBA 03/2024 - 12/2014
8	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2013 - 09/2007
6	maralixibatIBA 12/2023 - 10/2018
5	LipidsIBA 01/2024 - 09/2007
5	bile acid binding proteinsIBA 12/2023 - 08/2002
5	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2018 - 10/2006
5	LigandsIBA 08/2013 - 08/2005
4	SteroidsIBA 11/2022 - 05/2014
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2020 - 11/2008
3	sodium-bile acid cotransporterIBA 11/2023 - 01/2017
3	odevixibatIBA 08/2023 - 09/2020
3	RNA (Ribonucleic Acid)IBA 01/2023 - 06/2010
3	EnzymesIBA 01/2023 - 01/2008
3	VitaminsIBA 01/2022 - 09/2012
3	Alanine Transaminase (SGPT)IBA 01/2022 - 09/2014
3	AlbuminsIBA 12/2020 - 09/2014
3	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 11/2020 - 09/2014
3	Intravenous Immunoglobulins (IVIG)FDA Link 05/2019 - 10/2009
3	CytokinesIBA 06/2006 - 08/2002
2	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2006
2	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2016
2	1- (4- (4- (3,3- dibutyl- 7- (dimethylamino)- 2,3,4,5- tetrahydro- 4- hydroxy- 1,1- dioxido- 1- benzothiepin- 5- yl)phenoxy)butyl)- 4- aza- 1- azoniabicyclo(2.2.2)octaneIBA 01/2020 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2012
2	CholesterolIBA 01/2016 - 03/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 09/2013
2	Phytosterols (Plant Sterols)IBA 10/2013 - 09/2007
2	StigmasterolIBA 10/2013 - 09/2007
2	Retinoid X Receptors (Retinoid X Receptor)IBA 08/2013 - 02/2012
2	Phosphotransferases (Kinase)IBA 06/2010 - 11/2009
2	CurcuminIBA 04/2010 - 08/2002
2	Retinoid X Receptor alphaIBA 11/2009 - 01/2008
2	EndotoxinsIBA 08/2004 - 08/2002
1	Matrix Metalloproteinase 7 (Matrilysin)IBA 03/2024
1	ProteomeIBA 01/2023
1	EndoglinIBA 01/2023
1	PeriostinIBA 01/2023
1	Blood Proteins (Serum Proteins)IBA 01/2023
1	Carrier Proteins (Binding Protein)IBA 01/2023
1	ImmunosorbentsIBA 01/2023
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2023
1	Matrix Metalloproteinases (MMPs)IBA 01/2023
1	Connective Tissue Growth FactorIBA 01/2023
1	Matrix Metalloproteinase InhibitorsIBA 01/2023
1	Losartan (Cozaar)FDA LinkGeneric 01/2022
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2020
1	AntipruriticsIBA 07/2020
1	CDAA (Randox)IBA 01/2020
1	Amino Acids FDA Link 01/2020
1	Choline (Choline Chloride)IBA 01/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 05/2019
1	HLA-DR Antigens (HLA-DR)IBA 05/2019
1	CatecholaminesIBA 10/2018
1	AcidsIBA 10/2018
1	Cholic AcidIBA 10/2018

Therapy/Procedure

21	Liver Transplantation 12/2023 - 10/2002
17	Therapeutics 12/2023 - 10/2006
8	Hepatic Portoenterostomy 03/2024 - 05/2014
6	Transplantation 08/2013 - 11/2005
5	Parenteral Nutrition 01/2017 - 11/2006
2	Ligation 11/2023 - 01/2023
2	Drug Therapy (Chemotherapy) 01/2022 - 11/2008
2	Hepatectomy 11/2008 - 08/2002
1	Ambulatory Care (Outpatient Care) 01/2023